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Resveratrol reduces vascular cell senescence through attenuation of oxidative stress by SIRT1/NADPH oxidase-dependent mechanisms
27 January 2012
Yuhan Tang, Jian Xu, Wei Qu, Xiaolin Peng, Peng Xin, Xuefeng Yang, Chenjiang Ying, Xiufa Sun, Liping Hao
Abstract: Objective: Senescence of vascular cells contributes to the development of cardiovascular diseases and the overall aging. This study was undertaken to investigate the effects of resveratrol (...
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The soybean peptide aglycin regulates glucose homeostasis in type 2 diabetic mice via IR/IRS1 pathway
25 January 2012
Jingli Lu, Ying Zeng, Wenrui Hou, Shasha Zhang, Lulu Li, Xiang Luo, Wei Xi, Zhengwang Chen, Ming Xiang
Abstract: It has been previously reported that aglycin, a natural bioactive peptide isolated from soybean, is stable in digestive enzymes and has an antidiabetic potential. With a view to explore the ...
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Oit1/Fam3D, a gut-secreted protein displaying nutritional status-dependent regulation
09 January 2012
Nicole J.W. de Wit, Noortje IJssennagger, Els Oosterink, Shohreh Keshtkar, Guido J.E.J. Hooiveld, Ronald P. Mensink, Sebastiaan Hammer, Johannes W.A. Smit, Michael Müller, Roelof van der Meer
Abstract: Oncoprotein-induced transcript 1 (Oit1) was previously identified as a dietary fat-induced gene in the small intestine of C57Bl/6J mice. In this study, we further characterized Oit1 and its ...
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Coffee polyphenol caffeic acid but not chlorogenic acid increases 5′AMP-activated protein kinase and insulin-independent glucose transport in rat skeletal muscle
09 January 2012
Satoshi Tsuda, Tatsuro Egawa, Xiao Ma, Rieko Oshima, Eriko Kurogi, Tatsuya Hayashi
Abstract: Chlorogenic acid is an ester of caffeic and quinic acids, and is one of the most widely consumed polyphenols because it is abundant in foods, especially coffee. We explored whether chlorogen...
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Licochalcone E activates Nrf2/antioxidant response element signaling pathway in both neuronal and microglial cells: therapeutic relevance to neurodegenerative disease
09 January 2012
Sa Suk Kim, Juhee Lim, Yeojin Bang, Jiyeong Gal, Sang-Uk Lee, Young-Chang Cho, Goo Yoon, Bok Yun Kang, Seung Hoon Cheon, Hyun Jin Choi
Abstract: Oxidative stress and neuroinflammation are hallmarks of neurodegenerative diseases, which do not play independently but work synergistically through complex interactions exacerbating neurode...
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